Article
G13A substitution affects the biochemical and physical properties of the elongation factor 1 alpha. A reduced intrinsic GTPase activity is partially restored by kirromycin.
Biochemistry - 15 Jan 2002
Masullo Mariorosario, Cantiello Piergiuseppe, de Paola Barbara, Catanzano Francesca, Arcari Paolo, Bocchini Vincenzo
Abstract excerpt
The G13A substitution in the G13XXXXGK[T,S] consensus sequence of the elongation factor 1 alpha from the archaeon Sulfolobus solfataricus (SsEF-1 alpha) was introduced in order to study the reasons for selective differences found in the homologous consensus element AXXXXGK[T,S] of the other elongation factor EF-2 or EF-G. In a previous work, it was shown that the main effect of the A26G mutation was the...
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