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Article

Gene defect in ectodermal dysplasia implicates a death domain adapter in development.

Nature - 1 Jan 2000

Headon D J, Emmal S A, Ferguson B M, Tucker A S, Justice M J, Sharpe P T, Zonana J, Overbeek P A

Abstract excerpt

Members of the tumour-necrosis factor receptor (TNFR) family that contain an intracellular death domain initiate signalling by recruiting cytoplasmic death domain adapter proteins. Edar is a death domain protein of the TNFR family that is required for the development of hair, teeth and other ectodermal derivatives. Mutations in Edar-or its ligand, Eda-cause hypohidrotic ectodermal dysplasia in humans and mice....

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Topics

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Share to Ectodermal Dysplasia
Share to Edar Receptor
Share to Gene Expression

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Inbred C3H

Share to NF-kappa B

Share to Protein Structure, Tertiary

Share to Receptors, Tumor Necrosis Factor

Share to Sequence Homology, Amino Acid

Source

Identifiers

PMID: 11780064
DOI: 10.1038/414913a

Genes

EDARADD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene defect in ectodermal dysplasia implicates a death domain adapter in development.PMID 11780064Read ↗

Identification of a novel death domain-containing adaptor molecule for ectodysplasin-A receptor that is mutated in crinkled mice.Semantic proximity Read ↗

Edar/Eda interactions regulate enamel knot formation in tooth morphogenesis.Semantic proximity Read ↗

Mutations in the human homologue of mouse dl cause autosomal recessive and dominant hypohidrotic ectodermal dysplasia.Semantic proximity Read ↗

TRAF6-deficient mice display hypohidrotic ectodermal dysplasia.Semantic proximity Read ↗

TAB2, TRAF6 and TAK1 are involved in NF-kappaB activation induced by the TNF-receptor, Edar and its adaptator Edaradd.Semantic proximity Read ↗

Regulation of hair follicle development by the TNF signal ectodysplasin and its receptor Edar.Semantic proximity Read ↗

Structural insights into pathogenic mechanism of hypohidrotic ectodermal dysplasia caused by ectodysplasin A variants.Semantic proximity Read ↗

Autosomal dominant anhidrotic ectodermal dysplasias at the EDARADD locus.Semantic proximity Read ↗

Molecular aspects of hypohidrotic ectodermal dysplasia.Semantic proximity Read ↗

The Tabby phenotype is caused by mutation in a mouse homologue of the EDA gene that reveals novel mouse and human exons and encodes a protein (ectodysplasin-A) with collagenous domains.Semantic proximity Read ↗

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Traf6 is essential for murine tooth cusp morphogenesis.Semantic proximity Read ↗

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