Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Regulation of hair follicle development by the TNF signal ectodysplasin and its receptor Edar.

Development (Cambridge, England) - 1 May 2002

Laurikkala Johanna, Pispa Johanna, Jung Han-Sung, Nieminen Pekka, Mikkola Marja, Wang Xiuping, Saarialho-Kere Ulpu, Galceran Juan, Grosschedl Rudolf, Thesleff Irma

Abstract excerpt

X-linked and autosomal forms of anhidrotic ectodermal dysplasia syndromes (HED) are characterized by deficient development of several ectodermal organs, including hair, teeth and exocrine glands. The recent cloning of the genes that underlie these syndromes, ectodysplasin (ED1) and the ectodysplasin A receptor (EDAR), and their identification as a novel TNF ligand-receptor pair suggested a role for TNF signaling...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Activins
Share to Ectoderm

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Ectodysplasins

Share to Edar Receptor

Share to Epidermal Cells

Share to Fish Proteins

Share to Hair Follicle

Share to Lymphoid Enhancer-Binding Factor 1

Source

Identifiers

PMID: 11973284
DOI: 10.1242/dev.129.10.2541

Genes

TNF
EDAR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Regulation of hair follicle development by the TNF signal ectodysplasin and its receptor Edar.PMID 11973284Read ↗

Ectodysplasin regulates the lymphotoxin-beta pathway for hair differentiation.Semantic proximity Read ↗

Ectodysplasin-A1 is sufficient to rescue both hair growth and sweat glands in Tabby miceSemantic proximity Read ↗

Involvement of a novel Tnf receptor homologue in hair follicle induction.Semantic proximity Read ↗

Inducible mEDA-A1 transgene mediates sebaceous gland hyperplasia and differential formation of two types of mouse hair folliclesSemantic proximity Read ↗

Edar and Troy signalling pathways act redundantly to regulate initiation of hair follicle developmentSemantic proximity Read ↗

Ectodysplasin signaling in development.Semantic proximity Read ↗

Edar/Eda interactions regulate enamel knot formation in tooth morphogenesis.Semantic proximity Read ↗

Mutations leading to X-linked hypohidrotic ectodermal dysplasia affect three major functional domains in the tumor necrosis factor family member ectodysplasin-A.Semantic proximity Read ↗

Hypohidrotic ectodermal dysplasia: clinical and molecular review.Semantic proximity Read ↗

Structural insights into pathogenic mechanism of hypohidrotic ectodermal dysplasia caused by ectodysplasin A variants.Semantic proximity Read ↗

Signaling and subcellular localization of the TNF receptor Edar.Semantic proximity Read ↗

Ectodysplasin A1 promotes placodal cell fate during early morphogenesis of ectodermal appendagesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.