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Article

Identification of a novel death domain-containing adaptor molecule for ectodysplasin-A receptor that is mutated in crinkled mice.

Current biology : CB - 5 Mar 2002

Yan Minhong, Zhang Zemin, Brady John Ridgway, Schilbach Sarah, Fairbrother Wayne J, Dixit Vishva M

Abstract excerpt

Hypohydrotic Ectodermal Dysplasia (HED) is a genetic disease seen in humans and mice. It is characterized by loss of hair, sweat glands, and teeth. The predominant X-linked form results from mutations in ectodysplasin-A (EDA), a TNF-like ligand. A phenotypically indistinguishable autosomal form of the disease results from mutations in the receptor for EDA (EDAR). EDAR is a NF-kappaB-activating, death...

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Source

Identifiers

PMID: 11882293
DOI: 10.1016/s0960-9822(02)00687-5

Genes

EDAR
EDA
TNF
TRAF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Identification of a novel death domain-containing adaptor molecule for ectodysplasin-A receptor that is mutated in crinkled mice.PMID 11882293Read ↗

Gene defect in ectodermal dysplasia implicates a death domain adapter in development.Semantic proximity Read ↗

Ectodysplasin signaling in development.Semantic proximity Read ↗

Mutations in the human homologue of mouse dl cause autosomal recessive and dominant hypohidrotic ectodermal dysplasia.Semantic proximity Read ↗

Disease causing mutations in the TNF and TNFR superfamilies: Focus on molecular mechanisms driving disease.Semantic proximity Read ↗

Structural insights into pathogenic mechanism of hypohidrotic ectodermal dysplasia caused by ectodysplasin A variants.Semantic proximity Read ↗

Mutations leading to X-linked hypohidrotic ectodermal dysplasia affect three major functional domains in the tumor necrosis factor family member ectodysplasin-A.Semantic proximity Read ↗

The Ectodysplasin receptor EDAR acts as a tumor suppressor in melanoma by conditionally inducing cell death.Semantic proximity Read ↗

Molecular aspects of hypohidrotic ectodermal dysplasia.Semantic proximity Read ↗

Role of TRAF3 and -6 in the activation of the NF-kappa B and JNK pathways by X-linked ectodermal dysplasia receptor.Semantic proximity Read ↗

A founder ectodysplasin A receptor (EDAR) mutation results in a high frequency of the autosomal recessive form of hypohidrotic ectodermal dysplasia in India.Semantic proximity Read ↗

TAB2, TRAF6 and TAK1 are involved in NF-kappaB activation induced by the TNF-receptor, Edar and its adaptator Edaradd.Semantic proximity Read ↗

Autosomal dominant anhidrotic ectodermal dysplasias at the EDARADD locus.Semantic proximity Read ↗

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