Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Replacement of (alpha)1-Na-K-ATPase of Dahl rats by Milan rats lowers blood pressure but does not affect its activity.

Physiological genomics - 21 Dec 2001

Orlov S N, Dutil J, Hamet P, Deng A Y

Abstract excerpt

Both linkage and use of congenic strains have shown that a chromosome region near the gene for the Na-K-ATPase alpha(1)-subunit (Atp1a1) contained a quantitative trait locus (QTL) for blood pressure (BP). Currently, two congenic strains, designated S.M5 and S.M6, were made by replacing a segment of the Dahl salt-sensitive SS/Jr (S) rat by the homologous region of the Milan normotensive rat (MNS). In S.M5, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Sodium Chloride, Dietary
Share to Erythrocytes
Share to Gene Targeting

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Ion Transport

Share to Ouabain

Share to Rats, Inbred Dahl

Share to Rats, Inbred Strains

Share to Sodium-Potassium-Exchanging ATPase

Source

Identifiers

PMID: 11773603
DOI: 10.1152/physiolgenomics.00059.2001

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Replacement of (alpha)1-Na-K-ATPase of Dahl rats by Milan rats lowers blood pressure but does not affect its activity.PMID 11773603Read ↗

Genetic analysis of the SA and Na+/K+-ATPase alpha1 genes in the Milan hypertensive rat.Semantic proximity Read ↗

Failure of alleles at the Na+, K(+)-ATPase alpha 1 locus to cosegregate with blood pressure in Dahl rats.Semantic proximity Read ↗

Isolation of a chromosome 1 region that contributes to high blood pressure and salt sensitivity.Semantic proximity Read ↗

Congenic mapping of a blood pressure QTL region on rat chromosome 10 using the Dahl salt-sensitive rat with introgressed alleles from the Milan normotensive strain.Semantic proximity Read ↗

Congenic substitution mapping excludes Sa as a candidate gene locus for a blood pressure quantitative trait locus on rat chromosome 1.Semantic proximity Read ↗

Alteration of alpha 1 Na+,K(+)-ATPase 86Rb+ influx by a single amino acid substitution.Semantic proximity Read ↗

The alpha1 Na,K-ATPase gene is a susceptibility hypertension gene in the Dahl salt-sensitiveHSD rat.Semantic proximity Read ↗

The Atp1a1 gene from inbred Dahl salt sensitive rats does not contain the A1079T missense transversion.Semantic proximity Read ↗

Role of chromosome X in the Sabra rat model of salt-sensitive hypertension.Semantic proximity Read ↗

Successful isolation of a rat chromosome 1 blood pressure quantitative trait locus in reciprocal congenic strains.Semantic proximity Read ↗

A quantitative trait locus for aortic smooth muscle cell number acting independently of blood pressure: implicating the angiotensin receptor AT1B gene as a candidate.Semantic proximity Read ↗

Genetic analysis of rat chromosome 1 and the Sa gene in spontaneous hypertension.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.