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Article

Study of the association with -330T/G IL-2 in a population of centenarians from centre and south Italy.

Biogerontology - 1 Dec 2005

Scola Letizia, Candore Giuseppina, Colonna-Romano Giuseppina, Crivello Antonio, Forte Giusi I, Paolisso Giuseppe, Franceschi Claudio, Lio Domenico, Caruso Calogero

Abstract excerpt

Immune response in elderly is characterised by a progressive loss of the ability to cope environmental stressors with a characteristic remodelling of cytokine network. One of the data constantly reported in literature is the decrease of IL-2 production. An IL-2 central role in the reconstitution of T cell function in vitro is largely documented. Studies on a T-->G polymorphism at -330 nt of IL-2 gene promoter...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 16518704
DOI: 10.1007/s10522-005-4909-9

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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