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Article

Chondrogenic activity of the heparan sulfate proteoglycan perlecan maps to the N-terminal domain I.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jan 2002

French Margaret M, Gomes Ronald R, Timpl Rupert, Höök Magnus, Czymmek Kirk, Farach-Carson Mary C, Carson Daniel D

Abstract excerpt

C3H10T1/2 cells differentiate along a chondrogenic pathway when plated onto the extracellular matrix (ECM) protein perlecan (Pln). To identify the region(s) within the large Pln molecule that provides a differentiation signal, recombinant Pln-sequence-based polypeptides representing distinct structural domains were assayed for their ability to promote chondrogenesis in C3H10T1/2 cells. Five distinct domains,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 11771669
DOI: 10.1359/jbmr.2002.17.1.48
PMCID: PMC1774590

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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