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Article

Differentiation-induced loss of heparan sulfate in human exostosis derived chondrocytes.

Differentiation; research in biological diversity - 1 Jun 2005

Hecht Jacqueline T, Hayes Elizabeth, Haynes Richard, Cole William G, Long Robert J, Farach-Carson Mary C, Carson Daniel D

Abstract excerpt

An exostosis or osteochondroma is an aberrant bony growth occurring next to the growth plate either as an isolated growth abnormality or as part of the Hereditary Multiple Exostosis (HME) syndrome. Mutations in either exostosin 1 (EXT1) or exostosin 2 (EXT2) gene cause the HME syndrome and also some isolated osteochondromas. The EXT1 and EXT2 genes are glycosyltransferases that function as hetero-oligomers in the...

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Source

Identifiers

PMID: 16026543
DOI: 10.1111/j.1432-0436.2005.00025.x

Genes

EXT1
EXT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Differentiation-induced loss of heparan sulfate in human exostosis derived chondrocytes.PMID 16026543Read ↗

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Heparan sulfate as a regulator of endochondral ossification and osteochondroma developmentSemantic proximity Read ↗

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