Article

Podocalyxin and ciliary neurotrophic factor receptor are novel components of the surfaceome of chondrogenic cells

2025-05-21

Abstract excerpt

<h4>Background</h4> Osteoarthritis is a degenerative joint disease characterized by progressive loss of articular cartilage and limited capacity for intrinsic repair. A major barrier to developing effective regenerative strategies is the incomplete understanding of the molecular mechanisms regulating chondrogenesis and cartilage maintenance. Cell surface proteins are key mediators of extracellular communication,...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9452d51d-5b01-5b1d-9038-47f271c6f48b
DOI: 10.1101/2025.05.19.654853

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Podocalyxin and ciliary neurotrophic factor receptor are novel components of the surfaceome of chondrogenic cellsDOI 10.1101/2025.05.19.654853Read

Integrative Spatial Proteomics and Single-Cell RNA Sequencing Unveil Molecular Complexity in Rheumatoid Arthritis for Novel Therapeutic TargetingSemantic proximity Read

Craniofacial chondrogenesis in organoids from human stem cell-derived neural crest cellsSemantic proximity Read

Patient iPSC-Derived Cartilage Organoids Reveal Defective ECM Deposition and Altered Chondrogenic Trajectory in Saul-Wilson SyndromeSemantic proximity Read

Mechanisms and Regulatory Networks of Extracellular Matrix-Related Proteins in Cartilage Degeneration of OsteoarthritisSemantic proximity Read

Comparative quantification of the surfaceome of human multipotent mesenchymal progenitor cells.Semantic proximity Read

Deep phenotyping of ATDC5-derived in vitro cartilage organoidsSemantic proximity Read

Cross-Platform Transcriptomic Validation Identifies SERPINB2 as a Robust Chondrogenic Biomarker and Reveals Coordinated SERPIN Network Activation During Cartilage Lineage CommitmentSemantic proximity Read

Lyophilized Cell-Secreted Matrix as a Bioactive Substrate for Chondrocyte Expansion and RedifferentiationSemantic proximity Read

Extracellular matrices of bone marrow stroma regulate cell phenotype and contribute to distinct stromal niches <i>in vivo</i>Semantic proximity Read

Plasma Membrane Proteomics of Human Embryonic Stem Cells and Human Embryonal Carcinoma CellsSemantic proximity Read

The clusterin connectome: Emerging players in chondrocyte biology and putative exploratory biomarkers of osteoarthritisSemantic proximity Read

RNA-Seq analysis and comparison of corneal epithelium in keratoconus and myopia patientsSemantic proximity Read