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Article

Role of perlecan in skeletal development and diseases.

Glycoconjugate journal - 1 Jan 2000

Hassell John, Yamada Yoshihiko, Arikawa-Hirasawa Eri

Abstract excerpt

Perlecan, a large heparan sulfate proteoglycan (HSPG), is present in the basement membrane and other extracellular matrices. Its protein core is 400 kDa in size and consists of five distinct structural domains. A number of in vitro studies suggest multiple functions of perlecan in cell growth and differentiation and tissue organization. Recent studies with gene knockout mice and human diseases revealed critical...

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Identifiers

PMID: 12975604
DOI: 10.1023/A:1025340215261

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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