Article
pncA mutations as a major mechanism of pyrazinamide resistance in Mycobacterium tuberculosis: spread of a monoresistant strain in Quebec, Canada.
Antimicrobial agents and chemotherapy - 1 Mar 2000
Cheng S J, Thibert L, Sanchez T, Heifets L, Zhang Y
Abstract excerpt
Pyrazinamide (PZA) is an important first-line tuberculosis drug that is part of the currently used short-course tuberculosis chemotherapy. PZA is a prodrug that has to be converted to the active form pyrazinoic acid by pyrazinamidase (PZase) activity, encoded by the pncA gene of Mycobacterium tuberculosis, and loss of PZase activity is associated with PZA resistance. To further define the genetic basis of PZA...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.