Article
Phosphoinositide 3-kinase and Bruton's tyrosine kinase regulate overlapping sets of genes in B lymphocytes.
Proceedings of the National Academy of Sciences of the United States of America - 8 Jan 2002
Fruman David A, Ferl Gregory Z, An Sam S, Donahue Amber C, Satterthwaite Anne B, Witte Owen N
Abstract excerpt
Bruton's tyrosine kinase (Btk) acts downstream of phosphoinositide 3-kinase (PI3K) in a pathway required for B cell receptor (BCR)-dependent proliferation. We used DNA microarrays to determine what fraction of genes this pathway influences and to investigate whether PI3K and Btk mediate distinct gene regulation events. As complete loss-of-function mutations in PI3K and Btk alter B cell subpopulations and may...
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