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Article

Obligate roles for p16(Ink4a) and p19(Arf)-p53 in the suppression of murine pancreatic neoplasia.

Molecular and cellular biology - 1 Jan 2002

Bardeesy Nabeel, Morgan Jeffrey, Sinha Manisha, Signoretti Sabina, Srivastava Shefali, Loda Massimo, Merlino Glenn, DePinho Ronald A

Abstract excerpt

Epithelial tumors of the pancreas exhibit a wide spectrum of histologies with varying propensities for metastasis and tissue invasion. The histogenic relationship among these tumor types is not well established; moreover, the specific role of genetic lesions in the progression of these malignancies is largely undefined. Transgenic mice with ectopic expression of transforming growth factor alpha (TGF-alpha) in the...

Topics

Animals
Cyclin-Dependent Kinase Inhibitor p16
Cystadenoma, Serous
Endothelial Growth Factors
Genes, Tumor Suppressor
Genes, p53
Humans
Ligases
Lymphokines
Mice

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mice, Inbred C57BL

Mice, Inbred CBA

Mice, Mutant Strains

Mice, Transgenic

Mutation

Pancreatic Neoplasms

Phenotype

Transforming Growth Factor alpha

Source

Open in PubMed Open full text

Identifiers

PMID: 11756558
DOI: 10.1128/MCB.22.2.635-643.2002
PMCID: PMC139752

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-11756558-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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