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Article

A murine tumor progression model for pancreatic cancer recapitulating the genetic alterations of the human disease.

Genes & development - 1 Feb 2001

Wagner M, Greten F R, Weber C K, Koschnick S, Mattfeldt T, Deppert W, Kern H, Adler G, Schmid R M

Abstract excerpt

This study describes a tumor progression model for ductal pancreatic cancer in mice overexpressing TGF-alpha. Activation of Ras and Erk causes induction of cyclin D1-Cdk4 without increase of cyclin E or PCNA in ductal lesions. Thus, TGF-alpha is able to promote progression throughout G1, but not S phase. Crossbreeding with p53 null mice accelerates tumor development in TGF-alpha transgenic mice dramatically. In...

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Identifiers

PMID: 11159909
DOI: 10.1101/gad.184701
PMCID: PMC312620

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PCNA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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