Article
Deletion mutation in the putative third intracellular loop of the rat neurotensin receptor abolishes polyphosphoinositide hydrolysis but not cyclic AMP formation in CHO-K1 cells.
Molecular pharmacology - 1 Sept 1994
Yamada M, Yamada M, Watson M A, Richelson E
Abstract excerpt
The tridecapeptide neurotensin is a putative neurotransmitter in the central nervous system. Previously, we showed that the rat neurotensin receptor expressed in CHO-K1 cells mediates polyphosphoinositide hydrolysis and cAMP formation. To further investigate these neurotensin receptor-mediated si...
Topics
- Amino Acid Sequence
- Animals
- Binding Sites
- CHO Cells
- Cricetinae
- Cyclic AMP
- Hydrolysis
- Molecular Sequence Data
- Mutation
- Neurotensin
- Phosphatidylinositol Phosphates
- Polymerase Chain Reaction
- Radioligand Assay
- Rats
- Receptors, Neurotensin
- Signal Transduction
- Transfection