Deletion mutation in the putative third intracellular loop of the rat neurotensin receptor abolishes polyphosphoinositide hydrolysis but not cyclic AMP formation in CHO-K1 cells.

Abstract excerpt

The tridecapeptide neurotensin is a putative neurotransmitter in the central nervous system. Previously, we showed that the rat neurotensin receptor expressed in CHO-K1 cells mediates polyphosphoinositide hydrolysis and cAMP formation. To further investigate these neurotensin receptor-mediated signal transduction systems, we constructed three deletion mutations in the putative third intracellular loop of this...

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