Article
Extracellular surface residues of the α1B-adrenoceptor critical for G protein-coupled receptor function.
Molecular pharmacology - 1 Jan 2015
Ragnarsson Lotten, Andersson Åsa, Thomas Walter G, Lewis Richard J
Abstract excerpt
Ligand binding and conformational changes that accompany signaling from G protein-coupled receptors (GPCRs) have mostly focused on the role of transmembrane helices and intracellular loop regions. However, recent studies, including several GPCRs cocrystallized with bound ligands, suggest that the extracellular surface (ECS) of GPCRs plays an important role in ligand recognition, selectivity, and binding, as well...
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