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Article

Retroposed copies of RET gene: a somatically acquired event in medullary thyroid carcinoma

9 Jul 2019

Abstract excerpt

BACKGROUND: Different pathogenic germline mutations in the RET oncogene are identified in MEN 2, a hereditary syndrome characterized by medullary thyroid carcinoma (MTC) and other endocrine tumors. Although genetic predisposition is recognized, not all RET mutation carriers will develop the disease during their lifetime or, likewise, RET mutation carriers belonging to the same family may present clinical...

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PMID: 31288802
DOI: 10.1186/s12920-019-0552-1

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