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Article

In vivo 11beta-HSD-2 activity: variability, salt-sensitivity, and effect of licorice.

Hypertension (Dallas, Tex. : 1979) - 1 Dec 2001

Ferrari P, Sansonnens A, Dick B, Frey F J

Abstract excerpt

Loss-of-function mutations or inhibition of 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD-2) results in overstimulation of the mineralocorticoid receptor by cortisol and causes salt-sensitive hypertension. Traditionally, 11beta-HSD-2 activity has been assessed by measurement of the urinary cortisol metabolite ratio (tetrahydrocortisol [THF]+5alpha-THF)/tetrahydrocortisone (THE). Recently, the ratio of...

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PMID: 11751713
DOI: 10.1161/hy1101.096112

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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