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Article

Detection of Urinary Exosomal HSD11B2 mRNA Expression: A Useful Novel Tool for the Diagnostic Approach of Dysfunctional 11β-HSD2-Related Hypertension.

Frontiers in endocrinology - 1 Jan 2021

De Santis Domenica, Castagna Annalisa, Danese Elisa, Udali Silvia, Martinelli Nicola, Morandini Francesca, Veneri Mariangela, Bertolone Lorenzo, Olivieri Oliviero, Friso Simonetta, Pizzolo Francesca

Abstract excerpt

Objective: Apparent mineralocorticoid excess (AME) is an autosomal recessive disorder caused by the 11β-hydroxysteroid dehydrogenase type 2 (11β-HSD2) enzyme deficiency, traditionally assessed by measuring either the urinary cortisol metabolites ratio (tetrahydrocortisol+allotetrahydrocortisol/tetrahydrocortisone, THF+5αTHF/THE) or the urinary cortisol/cortisone (F/E) ratio. Exosomal mRNA is an emerging...

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Identifiers

PMID: 34497581
DOI: 10.3389/fendo.2021.681974
PMCID: PMC8419411

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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