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Article

LINE-1 methylation is inherited in familial testicular cancer kindreds.

BMC medical genetics - 17 May 2010

Mirabello Lisa, Savage Sharon A, Korde Larissa, Gadalla Shahinaz M, Greene Mark H

Abstract excerpt

BACKGROUND: Testicular germ cell tumors (TGCT) are the most frequent cancers among young men. There is a clear familial component to TGCT etiology, but no high-penetrance susceptibility gene has been identified. Epigenetic aberrations of the genome represent an alternative mechanism for cancer susceptibility; and, studies suggest that epigenetic changes that influence cancer risk can be inherited through the...

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Identifiers

PMID: 20478068
DOI: 10.1186/1471-2350-11-77
PMCID: PMC2880977

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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