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Article

Inheritance of a cancer-associated MLH1 germ-line epimutation.

The New England journal of medicine - 15 Feb 2007

Hitchins Megan P, Wong Justin J L, Suthers Graeme, Suter Catherine M, Martin David I K, Hawkins Nicholas J, Ward Robyn L

Abstract excerpt

Persons who have hypermethylation of one allele of MLH1 in somatic cells throughout the body (a germ-line epimutation) have a predisposition for the development of cancer in a pattern typical of hereditary nonpolyposis colorectal cancer. By studying the families of two such persons, we found evidence that the epimutation was transmitted from a mother to her son but was erased in his spermatozoa. The affected...

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Share to Adaptor Proteins, Signal Transducing
Share to Colorectal Neoplasms, Hereditary Nonpolyposis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17301300
DOI: 10.1056/NEJMoa064522

Genes

MLH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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