Article
The [URE3] phenotype: evidence for a soluble prion in yeast.
EMBO reports - 1 Jan 2002
Fernandez-Bellot Eric, Guillemet Elisabeth, Ness Frederique, Baudin-Baillieu Agnes, Ripaud Leslie, Tuite Mick, Cullin Christophe
Abstract excerpt
The aggregation of the two yeast proteins Sup35p and Ure2p is widely accepted as a model for explaining the prion propagation of the phenotypes [PSI+] and [URE3], respectively. Here, we demonstrate that the propagation of [URE3] cannot simply be the consequence of generating large aggregates of Ure2p, because such aggregation can be found in some conditions that are not related to the prion state of Ure2p. A...
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