Article
The Drosophila Toll-9 activates a constitutive antimicrobial defense.
EMBO reports - 1 Jan 2002
Ooi James Y, Yagi Yoshimasa, Hu Xiaodi, Ip Y Tony
Abstract excerpt
The Toll family of transmembrane proteins participates in signaling infection during the innate immune response. We analyzed the nine Drosophila Toll proteins and found that wild-type Toll-9 behaves similar to gain-of-function Toll-1. Toll-9 activates strongly the expression of drosomycin, and utilizes similar signaling components to Toll-1 in activating the antifungal gene. The predicted protein sequence of...
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