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Article

Constitutive expression of a single antimicrobial peptide can restore wild-type resistance to infection in immunodeficient Drosophila mutants.

Proceedings of the National Academy of Sciences of the United States of America - 19 Feb 2002

Tzou Phoebe, Reichhart Jean-Marc, Lemaitre Bruno

Abstract excerpt

One of the characteristics of the host defense of insects is the rapid synthesis of a variety of potent antibacterial and antifungal peptides. To date, seven types of inducible antimicrobial peptides (AMPs) have been characterized in Drosophila. The importance of these peptides in host defense is supported by the observation that flies deficient for the Toll or Immune deficiency (Imd) pathway, which affects AMP...

Topics

Animals
Anti-Bacterial Agents
Anti-Infective Agents
Antifungal Agents
Antimicrobial Cationic Peptides
Bacterial Infections
Blotting, Northern
Drosophila melanogaster
Mass Spectrometry
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mycoses

Plasmids

Time Factors

Transgenes

Source

Open in PubMed Open full text

Identifiers

PMID: 11854512
DOI: 10.1073/pnas.042411999
PMCID: PMC122334

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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