Article
Identification of the motif in versican G3 domain that plays a dominant-negative effect on astrocytoma cell proliferation through inhibiting versican secretion and binding.
The Journal of biological chemistry - 27 Apr 2001
Wu Y, Zhang Y, Cao L, Chen L, Lee V, Zheng P S, Kiani C, Adams M E, Ang L C, Paiwand F, Yang B B
Abstract excerpt
This study was designed to investigate the mechanisms by which mutant versican constructs play a dominant-negative effect on astrocytoma cell proliferation. Although a mini-versican or a versican G3 construct promoted growth of U87 astrocytoma cells, a mini-versican lacking epidermal growth facto...
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