Article
Human colon carcinoma cells with increased invasive capacity obtained by selection for sialyl-dimeric LeX antigen.
Experimental cell research - 1 Sept 1991
Matsushita Y, Nakamori S, Seftor E A, Hendrix M J, Irimura T
Abstract excerpt
Sialyl-dimeric LeX antigen (NeuAc alpha 2-3Gal beta 1-4[Fuc-alpha 1-3] GlcNAc beta 1-3Gal beta 1-4[Fuc alpha 1-3]GlcNAc beta 1-R; SLX) is an oncodevelopmental carbohydrate antigen expressed both on glycolipids and on mucin-like glycoproteins in human colorectal carcinomas. The levels are higher in primary tumors at advanced stages than in tumors at early stages, and metastatic lesions contain a greater quantity...
Topics
- Antibodies, Monoclonal
- Cell Division
- Cell Separation
- Colorectal Neoplasms
- Genetic Variation
- Glycoproteins
- Humans
- Lewis X Antigen
- Molecular Weight
- N-Acetylneuraminic Acid
- Neoplasm Invasiveness