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FTDP-17 tau mutations decrease the susceptibility of tau to calpain I digestion.

FEBS letters - 12 Nov 1999

Yen S, Easson C, Nacharaju P, Hutton M, Yen S H

Abstract excerpt

Frontal temporal dementia and Parkinsonism linked to chromosome 17 (FTDP-17) is caused by splice site and missense mutations in the tau gene, and characterized by the accumulation of filamentous tau in cerebral neurons and glia. The missense mutations reduce the ability of tau to promote microtub...

Topics

Calpain
Chromosomes, Human, Pair 17
Dementia
Frontal Lobe
Humans
Immunoblotting
Kinetics
Mutation
Parkinsonian Disorders
Recombinant Proteins
Silver Staining
Time Factors
tau Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 10561502
DOI: 10.1016/s0014-5793(99)01427-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026. Prepared record publication-10561502-2026-08-31.1. Manifest publication-graph-cohort-2026-08-31.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 31 Aug 2026.

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