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Article

Essential role of mitochondria in apoptosis of cancer cells induced by the marine alkaloid Lamellarin D.

Molecular cancer therapeutics - 1 Dec 2009

Ballot Caroline, Kluza Jérome, Martoriati Alain, Nyman Ulrika, Formstecher Pierre, Joseph Bertrand, Bailly Christian, Marchetti Philippe

Abstract excerpt

Lamellarin D, a potent cytotoxic marine alkaloid, exerts its antitumor action through two complementary pathways: a nuclear route via topoisomerase I inhibition and a mitochondrial targeting. The present study was designed to investigate the contribution of these two pathways for apoptosis in can...

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Identifiers

PMID: 19952118
DOI: 10.1158/1535-7163.MCT-09-0639

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19952118-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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