Article
Genetics of Paget's disease of bone.
Current osteoporosis reports - 1 Sept 2014
Ralston Stuart H, Albagha Omar M E
Abstract excerpt
Paget's disease of bone (PDB) is a common condition, which is characterised by focal areas of increased and disorganized bone remodeling. Genetic factors play an important role in the disease. In some cases, Paget's disease is inherited in an autosomal dominant manner and the most common cause for this is a mutation in the SQSTM1 gene. Other familial cases have been linked to the OPTN locus on Chromosome 10p13...
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