Article
Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases.
Molecular cell - 1 Nov 2001
Zhou Y J, Chen M, Cusack N A, Kimmel L H, Magnuson K S, Boyd J G, Lin W, Roberts J L, Lengi A, Buckley R H, Geahlen R L, Candotti F, Gadina M, Changelian P S, O'Shea J J
Abstract excerpt
Janus kinases comprise carboxyterminal kinase, pseudokinase, SH2-like, and N-terminal FERM domains. We identified three patient-derived mutations in the FERM domain of Jak3 and investigated the functional consequences of these mutations. These mutations inhibited receptor binding and also abrogated kinase activity, suggesting interactions between the FERM and kinase domains. In fact, the domains were found to...
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