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Article

A regulating role of the JAK2 FERM domain in hyperactivation of JAK2(V617F).

The Biochemical journal - 27 Jan 2010

Zhao Lequn, Ma Yue, Seemann Joachim, Huang Lily Jun-shen

Abstract excerpt

JAK2 (Janus tyrosine kinase 2) is important for signalling through many cytokine receptors, and a gain-of-function JAK2 mutation in its pseudokinase domain, V617F, has been implicated in Philadelphia chromosome-negative myeloproliferative neoplasms. How this mutation hyperactivates JAK2 is poorly...

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Source

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Identifiers

PMID: 19929856
DOI: 10.1042/BJ20090615
PMCID: PMC8514084

Genes

JAK2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19929856-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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A regulating role of the JAK2 FERM domain in hyperactivation of JAK2(V617F).PMID 19929856Read ↗

The molecular regulation of Janus kinase (JAK) activationSemantic proximity Read ↗

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Unexpected effects of FERM domain mutations on catalytic activity of Jak3: structural implication for Janus kinases.Semantic proximity Read ↗

The Jak2V617F oncogene associated with myeloproliferative diseases requires a functional FERM domain for transformation and for expression of the Myc and Pim proto-oncogenesSemantic proximity Read ↗

A structure-function perspective of Jak2 mutations and implications for alternate drug design strategies: the road not taken.Semantic proximity Read ↗

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