Article
Chromosome dynamics in the yeast interphase nucleus.
Science (New York, N.Y.) - 7 Dec 2001
Heun P, Laroche T, Shimada K, Furrer P, Gasser S M
Abstract excerpt
Little is known about the dynamics of chromosomes in interphase nuclei. By tagging four chromosomal regions with a green fluorescent protein fusion to lac repressor, we monitored the movement and subnuclear position of specific sites in the yeast genome, sampling at short time intervals. We found that early and late origins of replication are highly mobile in G1 phase, frequently moving at or faster than 0.5...
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