Human red blood cells have an enhancing effect on the relative expansion of CD8+ T lymphocytes in vitro.

doi:10.1046/j.1365-2184.2001.00222.x

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Article

Human red blood cells have an enhancing effect on the relative expansion of CD8+ T lymphocytes in vitro.

Cell proliferation - 1 Dec 2001

Porto B, Fonseca A M, Godinho I, Arosa F A, Porto G

Abstract excerpt

The present study was designed to analyse the effect of red blood cells on T-cell proliferation and expansion. A comparative study was done in peripheral blood cell cultures stimulated with phytohemagglutinin, with or without red blood cells. The presence of red blood cells had a consistent enhancing effect on T lymphocyte proliferation, as determined by an increase in both the mitotic index and thymidine uptake....

Topics

CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Cell Division
Erythrocytes
Female
Flow Cytometry
Humans
Lymphoproliferative Disorders
Middle Aged
Mitosis
Oxidative Stress
Phenotype
Thymidine
Time Factors

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Open in PubMed Open full text

Identifiers

PMID: 11737000
DOI: 10.1046/j.1365-2184.2001.00222.x
PMCID: PMC6496493

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