Article
Expansion of CD8+ cells in autoimmune hemolytic anemia.
Autoimmunity - 1 Jan 2016
Smirnova S Ju, Sidorova Ju V, Tsvetaeva N V, Nikulina O F, Biderman B V, Nikulina E E, Kulikov S M, Sudarikov A B
Abstract excerpt
Autoimmune hemolytic anemia (AIHA) is a rare blood disease associated with the production of auto-antibodies and autoimmune hemolysis. A critical role of B-cells in the development of AIHA has been demonstrated before. Here, we present the analysis of the clonal T-cell populations in patients with AIHA. Thirty-three patients with AIHA were included in this study. Thirteen patients with other anemias, 14 patients...
Topics
- Adolescent
- Adult
- Aged
- Anemia, Hemolytic, Autoimmune
- Antigens, Surface
- Base Sequence
- CD8-Positive T-Lymphocytes
- Erythrocyte Indices
- Female
- Gene Rearrangement, B-Lymphocyte
- Gene Rearrangement, T-Lymphocyte
- Humans
- Immunophenotyping
- Lymphocyte Count
- Male
- Middle Aged
- Phenotype
- Sequence Analysis, DNA