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Unusual CD4+CD8+ phenotype in a greek patient diagnosed with adult T-cell leukemia positive for human T-cell leukemia virus type I (HTLV-I).

Leukemia research - 1 Apr 2000

Ciminale V, Hatziyanni M, Felber B K, Bear J, Hatzakis A, Pavlakis G N

Abstract excerpt

We describe the first Greek patient diagnosed with Adult T cell leukemia (ATL) characterized by an expansion of CD4+CD8+ double positive lymphocytes. Low levels of plasma antibodies against HTLV-I Env and Gag proteins were detected. Analysis of the the patient's DNA revealed that she was infected by a cosmopolitan strain of HTLV-I. Since HTLV-I usually leads to the expansion of CD4+ cells, this patient...

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PMID: 10713333
DOI: 10.1016/s0145-2126(99)00193-9

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