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Article

Modifying the specificity of an RNA backbone contact.

Journal of molecular biology - 7 Dec 2001

Dertinger D, Dale T, Uhlenbeck O C

Abstract excerpt

The interaction between the MS2 bacteriophage coat protein homodimer and its cognate RNA hairpin is facilitated by 21 different RNA-protein contacts. In one of these contacts, the 2'-hydroxyl group at ribose -5 of the RNA acts as a hydrogen bond donor to Glu63 in one subunit of the protein. Previous experiments showed that substitution of ribose -5 with deoxyribose resulted in a 24-fold decrease in binding...

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Source

Identifiers

PMID: 11733985
DOI: 10.1006/jmbi.2001.5132

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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