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Article

Cytoplasmic expression of mouse prion protein causes severe toxicity in Caenorhabditis elegans.

Biochemical and biophysical research communications - 8 Aug 2008

Park Kyung-Won, Li Liming

Abstract excerpt

To test if Caenorhabditis elegans could be established as a model organism for prion study, we created transgenic C. elegans expressing the cytosolic form of the mouse prion protein, MoPrP(23-231), which lacks the N-terminal signal sequence and the C-terminal glycosylphosphatidylinisotol (GPI) anchor site. We report here that transgenic worms expressing MoPrP(23-231)-CFP exhibited a wide range of distinct...

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Source

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Identifiers

PMID: 18519028
DOI: 10.1016/j.bbrc.2008.05.132
PMCID: PMC2587115

Genes

CFP
GPI

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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