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Article

Genetic and biochemical basis for viability of yeast lacking mitochondrial genomes.

Genetics - 1 Dec 2002

Kominsky Douglas J, Brownson Mary P, Updike Dustin L, Thorsness Peter E

Abstract excerpt

Yme1p, an ATP-dependent protease localized in the mitochondrial inner membrane, is required for the growth of yeast lacking an intact mitochondrial genome. Specific dominant mutations in the genes encoding the alpha- and gamma-subunits of the mitochondrial F(1)F(0)-ATPase suppress the slow-growth phenotype of yeast that simultaneously lack Yme1p and mitochondrial DNA. F(1)F(0)-ATPase activity is reduced in yeast...

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Identifiers

PMID: 12524335
DOI: 10.1093/genetics/162.4.1595
PMCID: PMC1462355

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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