Article
From integrative genomics to systems genetics in the rat to link genotypes to phenotypes.
Disease models & mechanisms - 1 Oct 2016
Moreno-Moral Aida, Petretto Enrico
Abstract excerpt
Complementary to traditional gene mapping approaches used to identify the hereditary components of complex diseases, integrative genomics and systems genetics have emerged as powerful strategies to decipher the key genetic drivers of molecular pathways that underlie disease. Broadly speaking, integrative genomics aims to link cellular-level traits (such as mRNA expression) to the genome to identify their genetic...
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