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Article

Phosphatidylinositol 3-kinase p85{alpha} subunit-dependent interaction with BCR/ABL-related fusion tyrosine kinases: molecular mechanisms and biological consequences.

Molecular and cellular biology - 1 Sept 2005

Ren Shu-Yue, Bolton Elisabeth, Mohi M Golam, Morrione Andrea, Neel Benjamin G, Skorski Tomasz

Abstract excerpt

The p85alpha subunit of phosphatidylinositol 3-kinase (PI-3k) forms a complex with a protein network associated with oncogenic fusion tyrosine kinases (FTKs) such as BCR/ABL, TEL/ABL, TEL/JAK2, TEL/PDGFbetaR, and NPM/ALK, resulting in constitutive activation of the p110 catalytic subunit of PI-3k. Introduction of point mutations in the N-terminal and C-terminal SH2 domain and SH3 domain of p85alpha, which disrupt...

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Source

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Identifiers

PMID: 16135792
DOI: 10.1128/MCB.25.18.8001-8008.2005
PMCID: PMC1234343

Genes

BCR
ALK
JAK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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