Characterization of three new imatinib-responsive fusion genes in chronic myeloproliferative disorders generated by disruption of the platelet-derived growth factor receptor   gene

Abstract excerpt

BACKGROUND AND OBJECTIVES: We sought to identify new fusion genes with involvement of the platelet-derived growth factor receptor beta gene (PDGFRB) in three patients presenting with various subtypes of chronic myeloproliferative disorders associated with chromosomal aberrations involving chromosome bands 5q31-33. DESIGN AND METHODS: We performed 5 rapid amplification of cDNA ends (5 -RACE)-polymerase chain...

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