Article
Androgen-receptor defect abolishes sex differences in nitric oxide and reactivity to vasopressin in rat aorta.
Journal of applied physiology (Bethesda, Md. : 1985) - 1 Dec 2001
Stallone J N, Salisbury R L, Fulton C T
Abstract excerpt
Contractions of rat thoracic aorta to vasopressin (VP) are threefold higher in females (F) than in males (M), primarily because nitric oxide (NO) attenuation of contraction is greater in M. To determine the role of the androgen receptor (AR) in this mechanism, vascular reactivity to VP was examined in thoracic aorta of the testicular-feminized male (Tfm) rat, which has an X-linked, recessive defect in AR function...
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