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Article

Does apolipoprotein E (Apo-E) genotype influence nicotinic receptor binding in Alzheimer's disease.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Jan 2001

Reid R T, Sabbagh M N, Thal L J

Abstract excerpt

We wished to determine the influence of the apolipoprotein E (Apo-E) genotype on the loss of high affinity nicotinic acetylcholine receptor (nAChR) binding in Alzheimer's disease (AD). The interaction between epsilon4 allele gene dose and cholinergic loss in AD remains controversial. We have demonstrated that nicotinic binding is significantly lost in AD. Tissue from the midfrontal (MF) cortex of 7 subjects with...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 11716140
DOI: 10.1007/s007020170023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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