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Article

E4 allele dosage does not predict cholinergic activity or synapse loss in Alzheimer's disease.

Neurology - 25 Jan 2000

Corey-Bloom J, Tiraboschi P, Hansen L A, Alford M, Schoos B, Sabbagh M N, Masliah E, Thal L J

Abstract excerpt

OBJECTIVE: To investigate the relationship between apolipoprotein E (APOE) genotype and both cholinergic dysfunction and synapse loss in AD. BACKGROUND: A reduction in neocortical synapses and marked losses in the cholinergic system occur in AD. It has been suggested that the number of APOE epsilon4 alleles is inversely related to choline acetyltransferase (ChAT) activity, thereby influencing cholinergic...

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Source

Identifiers

PMID: 10668702
DOI: 10.1212/wnl.54.2.403

Genes

APOE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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