Article
Nicotinic receptors, muscarinic receptors and choline acetyltransferase activity in the temporal cortex of Alzheimer patients with differing apolipoprotein E genotypes.
Neuroscience letters - 22 Aug 1997
Svensson A L, Warpman U, Hellström-Lindahl E, Bogdanovic N, Lannfelt L, Nordberg A
Abstract excerpt
The number of nicotinic and muscarinic receptors and choline acetyltransferase (ChAT) activity were investigated in the temporal cortex of patients with Alzheimer's disease (AD) with different apolipoprotein E (APOE) genotypes. A significant reduction in the ChAT activity (P < 0.001) and in the n...
Topics
- Aged
- Aged, 80 and over
- Alzheimer Disease
- Apolipoprotein E4
- Apolipoproteins E
- Choline O-Acetyltransferase
- Genotype
- Humans
- Middle Aged
- Receptors, Muscarinic
- Receptors, Nicotinic
- Temporal Lobe