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Article

Apolipoprotein E genotype and association between smoking and early onset Alzheimer's disease.

BMJ (Clinical research ed.) - 11 Mar 1995

van Duijn C M, Havekes L M, Van Broeckhoven C, de Knijff P, Hofman A

Abstract excerpt

OBJECTIVE: To investigate the hypothesis that differential survival between smokers and non-smokers leading to a decrease in the frequency of the e4 allele of the apolipoprotein E gene may explain the inverse relation between smoking history and early onset Alzheimer's disease. DESIGN: A populati...

Topics

Age of Onset
Alleles
Alzheimer Disease
Apolipoproteins E
Case-Control Studies
Female
Gene Frequency
Heterozygote
Humans
Male
Middle Aged
Netherlands
Odds Ratio

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Population Surveillance

Risk Factors

Smoking

Source

Open in PubMed Open full text

Identifiers

PMID: 7703749
DOI: 10.1136/bmj.310.6980.627
PMCID: PMC2549007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7703749-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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