Article
Genetic determinants of IL-6 expression levels do not influence bone loss in inflammatory bowel disease.
Digestive diseases and sciences - 1 Nov 2001
Schulte C, Goebell H, Röher H D, Schulte K M
Abstract excerpt
Bone loss in inflammatory bowel disease (IBD) is presumed to be mediated by inflammation. Increased levels of the multifunctional cytokine IL-6 in inflammatory diseases have been proposed to be the link in such "inflammation-mediated osteopenia." A recently described G/C polymorphism with an effect on transcription rate and plasma levels of IL-6 suggests a genetically determined difference in the degree of the...
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