Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impaired contextual fear conditioning in RasGRF2 mutant mice is likely Ras-ERK-dependent.

Neurobiology of learning and memory - 1 May 2021

Olevska Anastasia, Spanagel Rainer, Bernardi Rick E

Abstract excerpt

Ras/Raf/MEK/ERK (Ras-ERK) signaling has been shown to play an important role in fear acquisition. However, little information is known regarding the mechanisms that contribute to the regulation of this pathway in terms of the learning of conditioned fears. Ras Guanine Nucleotide Releasing Factor 2 (RasGRF2) is one of two guanine nucleotide exchange factors (GEF) that regulates the Ras-ERK signaling pathway in a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CA1 Region, Hippocampal
Share to Conditioning, Classical
Share to Fear

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to MAP Kinase Kinase Kinases

Share to Mitogen-Activated Protein Kinase 1

Share to Mitogen-Activated Protein Kinase 3

Share to rac1 GTP-Binding Protein

Share to raf Kinases

Source

Identifiers

PMID: 33831510
DOI: 10.1016/j.nlm.2021.107435

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impaired contextual fear conditioning in RasGRF2 mutant mice is likely Ras-ERK-dependent.PMID 33831510Read ↗

Behavioral and genetic architecture of fear conditioning and related phenotypes.Semantic proximity Read ↗

Contextual memory deficits observed in mice overexpressing small conductance Ca2+-activated K+ type 2 (KCa2.2, SK2) channels are caused by an encoding deficit.Semantic proximity Read ↗

Inducible, pharmacogenetic approaches to the study of learning and memory.Semantic proximity Read ↗

The Activating Transcription Factor 3 (Atf3) Homozygous Knockout Mice Exhibit Enhanced Conditioned Fear and Down Regulation of Hippocampal GELSOLINSemantic proximity Read ↗

Altered ERK/MAPK signaling in the hippocampus of the mrsk2_KO mouse model of Coffin-Lowry syndrome.Semantic proximity Read ↗

Trace eyeblink conditioning requires the hippocampus but not autophosphorylation of alphaCaMKII in mice.Semantic proximity Read ↗

Pavlovian fear memory circuits and phenotype models of PTSD.Semantic proximity Read ↗

Generalization of contextual fear is sex-specifically affected by high salt intakeSemantic proximity Read ↗

Impaired Pavlovian cued fear conditioning in Tg2576 mice expressing a human mutant amyloid precursor protein gene.Semantic proximity Read ↗

Impaired conditioned fear and enhanced long-term potentiation in Fmr2 knock-out mice.Semantic proximity Read ↗

Salient Safety Conditioning Improves Novel Discrimination LearningSemantic proximity Read ↗

The maintenance of established remote contextual fear memory requires ERK5 MAP kinase and ongoing adult neurogenesis in the hippocampus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.