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Article

The knock-down of ERCC1 but not of XPF causes multinucleation.

DNA repair - 5 Sept 2011

Rageul Julie, Frëmin Christophe, Ezan Frédéric, Baffet Georges, Langouët Sophie

Abstract excerpt

Excision repair cross complementing gene 1 (ERCC1) associated with xeroderma pigmentosum group F (XPF) is a heterodimeric endonuclease historically involved in the excision of bulky helix-distorting DNA lesions during nucleotide excision repair (NER) but also in the repair of DNA interstrand crosslinks. ERCC1 deficient mice show severe growth retardation associated with premature replicative senescence leading to...

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Source

Identifiers

PMID: 21839691
DOI: 10.1016/j.dnarep.2011.07.005

Genes

ERCC1
XPC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The knock-down of ERCC1 but not of XPF causes multinucleation.PMID 21839691Read ↗

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First reported patient with human ERCC1 deficiency has cerebro-oculo-facio-skeletal syndrome with a mild defect in nucleotide excision repair and severe developmental failure.Semantic proximity Read ↗

Cells from ERCC1-deficient mice show increased genome instability and a reduced frequency of S-phase-dependent illegitimate chromosome exchange but a normal frequency of homologous recombination.Semantic proximity Read ↗

Mislocalization of XPF-ERCC1 nuclease contributes to reduced DNA repair in XP-F patients.Semantic proximity Read ↗

Disruption of mouse ERCC1 results in a novel repair syndrome with growth failure, nuclear abnormalities and senescence.Semantic proximity Read ↗

Function and Interactions of ERCC1-XPF in DNA Damage ResponseSemantic proximity Read ↗

A new multisystem ERCC1-hepatorenal syndrome: insights from a clinical cohort, molecular pathogenesis, and management guidelines.Semantic proximity Read ↗

ERCC1 mutations impede DNA damage repair and cause liver and kidney dysfunction in patients.Semantic proximity Read ↗

Identification of microRNAs dysregulated in cellular senescence driven by endogenous genotoxic stressSemantic proximity Read ↗

The ERCC1/XPF endonuclease is required for completion of homologous recombination at DNA replication forks stalled by inter-strand cross-links.Semantic proximity Read ↗

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