Article
Loss of heterozygosity and its correlation with clinical outcome and Epstein-Barr virus infection in nasopharyngeal carcinoma.
Anticancer research - 1 Jan 2000
Shao J Y, Huang X M, Yu X J, Huang L X, Wu Q L, Xia J C, Wang H Y, Feng Q S, Ren Z F, Ernberg I, Hu L F, Zeng Y X
Abstract excerpt
Sixty-one human nasopharyngeal carcinomas (NPC) were examined by allelotype analysis for the purposes of detecting potential association between loss of heterozygosity (LOH), clinicopathological parameters and Epstein-Barr virus (EBV) infection. LOH was performed using 257 polymorphic markers on 22 chromosomes. High frequency LOH (> or = 60%) was observed on 12 chromosome arms including 1p, 2p, 2q, 3p, 3q, 5q,...
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